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Ozone Inhalation - History Of Clinical Uses

Authority: August Caille, M.D.
Professor: Children's Diseases Post-Graduate Medical School, New York, N. Y.
Subject: OZONE - for Chlorosis (iron-deficiency anemia)
Increase of Oxyhemoglobin, Case Histories
The period of my observations extended over five months. Altogether this report embraces 22 cases. The salient points in the cases treated with OZONE inhalations are as follows:
Case 4. Chlorosis ant Anemia. E.V., 11 years old. Extreme anemia Cold skin. No appetite. Daily headache. No marked improvement after iron and arsenic. Vital capacity 90. Oxyhemoglobin 7%. OZONE inhalation twice daily for 15 minutes, for two weeks. Followed by a very great improvement. 11% oxyhemoglobin. Vital capacity 120. Warm skin. Good appetite. No headache.
Case 5. E.H., 22 years old. Oxyhemoglobin 8%. General condition and treatment as in case 4. After two weeks inhalations, 10% Oxyhemoglobin and general condition very good.
Case 6. Severe anemia since birth in a sickly looking and emaciated girl of 11 years. 5% oxyhemoglobin. Skin and mucous membranes white. General condition bad. No improvement after change of climate and iron, arsenic, phosphorus, etc. OZONE, 3 times daily for 10 weeks. Great change noticeable. Good color, warm skin, good appetite, no headache, great ambition to work and study. 10% oxyhemoglobin.
Case 7. Chlorosis. K. W., 19 years old. Menses acant, every 8 to 10 weeks. All other symptoms of great anemia present. Duration of illness 4 years. 8% oxyhemoglobin. OZONE inhalations daily for 10 weeks, during which time the menses appeared twice at proper intervals. 3% increases in oxyhemoglobin.
Case 8. Chlorosis. C. B., 20 years old. Much like case 7. No noteworthy improvement after iron. 8% oxyhemoglobin. OZONE inhalations daily for three months. Complete cure. 3% gain in oxyhemoglobin.
Case 9. Chronic Bronchitis and Great Anemia. A. A., 40 years old. 8% oxyhemoglobin. After daily inhalations for 2 months, great improvement in regards to anemia.
Case 10. Chlorosis and Nervous Prostration. E. S., 241 years old. Daily inhalations of OZONE for 4 weeks increased the oxyhemoglobin 3% and made further treatment unnecessary. No relapse after 2 months.
Case 11. Anemia and Chronic Naso-pharyngeal Catarrh. A. R., 20 years old. Oxyhemoglobin 9%. Cured after inhaling for 2 months and ended local treatment of Naso-pharynx. 3% gain in oxyhemoglobin.
Case 12 Chlorosis of long standing. E. K., 22 years old. Inhalation three months. All symptoms removed or much improved. 3% gain in oxyhemoglobin.
Case 13. Anemia in Tuberculosis of Cutis. M. C., 22 years old. Unable to attend to business. No effect from usual drugs. After three months inhalations is in excellent general condition, but the skin affection remains stationary. 2% increase in oxyhemoglobin.
Case 14. Extreme anemia from chronic lead poisoning. After 50 inhalations oxyhemoglobin increased 3%. No relapse after two months.
Pertussis: Seven cases, Children ranging from 18 months to 7 years. Each case well marked and of average severity. Two to three inhalations given daily. All cases discharged alter two weeks, except one which lasted four weeks. The improvement became manifest after the first three or four inhalations, as regards the severity and frequency of the spasmodic attacks. The children slept better during the night after OZONE inhalations, than before the treatments, and the youngest children under observation usually went to sleep after each inhalation. (Whooping Cough)
CONCLUSIONS: Daily Inhalations of Ozone Increases the Quantity of Oxyhemoglobin in the Blood from 1% to 4% in a Short Time.
In Pertussis, OZONE inhalations have a very distinct curative effect as regards the duration and severity of the disease. In Chlorosis and anemia, Ozone inhalations are exceedingly valuable from a therapeutic stand point and give better and prompter results than any other form of medication. Atmospheric medication is readily secured, making this probably a valuable procedure in the treatment of Diphtheria, Scarlet Fever and other infectious diseases.
I am convinced that it would be a value in Pernicious Anemia. The anemia children who came under treatment were very sick, especially the one case I referred to, in which everything had been tried, and it was really remarkable how soon this child picked up and became better in every way after inhaling OZONE. I was thoroughly surprised at the result.
In "Report to the American Society:" Boston, Mass.

Authority: George Stocker. M.D., C.M.G., M.R.C.P. Major R.A.M.C.
Subject: OZONE - for treatment of Consumption
OZONE INHALATION TREATMENT OF CONSUMPTION AND CATARRH
The difficulty and trouble required to obtain a good result has hitherto led to the unpopularity of this method in the medical profession, and want of a proper understanding of the right way in which to carry out the inhalation treatment has sometimes led to bad results when it has been tried.
Some years ago, Hass showed that it was possible to thoroughly impregnate the air of a closed room with volatile antiseptics so that a patient using the room could not avoid drawing the substances right down into the lung during the ordinary process of breathing. His experiment made it apparent that this principle was one of great importance AND ONLY WANTED A SUITABLE INVENTION OF AN APPARATUS TO BE OF VERY GREAT USE IN THE TREATMENT OF DISEASES OF THE LUNGS AND AIR PASSAGES.
IT IS UNQUESTIONABLE THAT EVERY METHOD OF INHALATION TREATMENT MUST BE CONTINUOUS IF IT IS TO BE EFFECTIVE.
Some of many case histories listed:
Female, age 23. Two brothers and one sister had died of consumption. The patient suffered with cough, muco-purulent expectoration and had haemoptysis. Tubercle bacilli were present in small quantities. She was under treatment for one month. The purulent character of her sputum and the tubercle bacilli quite disappeared. The haemoptysis ceased and the patient gained 4 pounds in weight.
Male, age 22. Several near relations died of consumption. Patient had large cavities in the apices of both lungs, repeated haemoptysis, profuse muco-purulent expectoration, night sweats, and severe cough. His average evening temperature was 102 and tubercle bacilli were present in large quantities. He was six months under treatment; at the end of this time his evening temperature was normal; the haemoptysis had ceased, the expectoration was healthy and the tubercle bacilli had disappeared and he gained 10.5 pounds in weight. The cavities had cicatried and contracted so much that the top of the left chest was fixed.
The most remarkable results of this system of treatment are to be seen in:
1. the reduction of the temperature, and
2. diminution and disappearance of the tubercle bacilli.
It may be stated that the patients had the usual meals, breakfast, lunch, tea and dinner or supper; in fact, had ordinary diets and the so-called "stuffing" system was not practiced.
In "Case Records'' and "British Lancet"

Authority: Joseph E. G. Waddington. M.D., C.M., American College of Physical Therapy
Subject: OZONE - for subnormal temperature and equalization of the blood
Cases of suboxidation usually have a subnormal temperature, ranging from as low as 96 degrees; as Health cannot be maintained below the normal standard of 98.6 degrees. THE SOONER THE CLINKERS OF IMPAIRED OXIDATION; DEFICIENT OR INCOMPLETE COMBUSTION, ARE REMOVED UNDER THE DISINTEGRATING AND STIMULATING DRAFT OF OZONE. THE SOONER WILL HEALTH BE APT TO BE RESTORED.
The visual evidence of the effect of Ozone upon oxidation is easily demonstrable by taking the temperature immediately before and after an Ozone inhalation, when a subnormal temperature will invariable show a raise after the inhalation, varying in degree directly with the extent of the subnormality.
Infection is usually, if not invariable, the etiologic factor in an elevated temperature, and infections naturally vary intensively in degree of virulence and consequent altitudinous stimulation of the thermal reaction. This being true, we can realize the apparent-though only superficially apparent-paradox of prescribing Ozone not alone for conditions evidencing subnormal body heat, BUT ALSO FOR CONDITIONS EVINCING JUST THE OPPOSITE EXTREME.
Ozone inhalations, to quote from Tousey, "INCREASE THE PROPORTION OF OXYHEMOGLOBIN if that is subnormal and also the number of red corpuscles, cause an increase in respiratory capacity and A REDUCTION IN WHITE BLOOD CELLS IF THEY ARE IN EXCESS."
Inhalation should be given daily and of a duration from 15 to 30 minutes, depending solely upon the susceptibility of the patient to treatment. Saturation of the system is evidenced by a feeling of cerebral fullness, dizziness, and even nausea if carried beyond a healthful mean.
In "Practical Index of Electro and Photo Therapy

Authority: George Stocker, M.D.. C.M.G., F.R.C.S., R.A., M.C.
Subject: OZONE - for Gas Poisoning
The idea of using Ozone inhalation in the treatment of cases of poison gas was first suggested to me by long experience of this treatment in diseases of the air passages, such as pneumonia, bronchitis, bronchientacis, etc., and also of cavities in the lungs and in empyena; by this most successful results were obtained.
I considered poison gas as a producer of what may be called a mechanical Pneumonia, as opposed to the more ordinary forms resulting from cold causes etc., and requires the same treatment.
The principal effects of Ozone are:
1. as a complete germicide
2. a strong factor in the formation of oxyhemoglobin and
3. a powerful stimulant to the heart.
When prepared from atmospheric air, with proper ozonizers, and care fully administered, it is absolutely NON-IRRITATING. If these precautions are not observed, it may produce irritation instead of relief. Ozone should be inhaled directly from the ozonizers air-tight chambers, such as are used in hospitals for the treatment of tubercular cases, are cumbersome and inconvenient, and not suitable for the advanced front. Ozone is a very evanescent body and soon loses its power and becomes oxygen again, and for these reasons should be inhaled direct from the ozonizer.
Ozone should be thus inhaled from 10 to 15 minutes at each application. The number of applications being dependent on:
1. the severity of the case
2. the toleration of it by the patient and
3. the relief afforded.

It must be remembered that the sooner Ozone is inhaled, even though for a short time at first, the better the result will be.
THE OBSERVED EFFECTS OF OZONE IN GASSED CASES ARE:
1. It relieves the cough, dyspones and pain.
2. It assists the expulsion of the glutinous mucous from the air passage.
3. It stimulates the heart's action and reduces its intermittence when this symptom shows.
4. In many cases of gassing, the mental condition of the patient is affected, they become dull, stupid and apathetic. OZONE RELIEVES AND BANISHES THESE CONDITIONS.
In "British Lancet"
Authorities: Drs. L. Abbe and Oudin, M.D., Paris, France
Subject: OZONE - for Treatment of Pulmonary Tuberculosis
Our observation of treatments of pulmonary tuberculosis by inhalation of OZONE covering three years includes 38 cases, seven being in the first stage and 23 in the second stage, with eight being in the final stage.
ALL WITHOUT EXCEPTION, EXPERIENCED CONSIDERABLE IMPROVEMENT, PERMANENT IN MOST CASES, AND THAT FOR SUCH LENGTH OF TIME, IN 13 CASES THAT WE CAN CONSIDER THEM CURED.
The first result of the treatment is the return of appetite, which soon becomes imperious, obliging patients to eat four or five times each day. Then one sees the lessening of the diarrhea, vomiting and sweats. This triple improvement is soon accompanied by the return of strength ant flesh.
ACCOMPANYING THIS RETURN OF FLESH THERE IS A CORRESPONDING INCREASE OF OXYHEMOGLOBIN, WHICH WAS EXAMINED IN ALL CASES BY HENOQUIES'S PROCESS OF HEMOTOSPECTROSCOPY.
The functional symptoms also improved very favorable and rapidly. The cough became more and more rare until it occurred only at awakening before finally disappearing altogether. The frothy expectorations became more solid and gradually less abundant.
Several of our patients had experienced spitting of blood, even frequent serious. In no case did it occur during the course of the treatment. The sore spots, the difficulty in breathing, disappeared gradually as the conditions improved and the fever also.
Among the patients in the first stage, at the end of two months at the most, there were no longer any abnormal noises. Even among patients in the first stage, we found noticeable stethoscopic modifications, as the disappearance of rales.
To the eloquent figures we have cited, we add only a few words to emphasize the fact that our patients have all, or nearly all, been drawn from the poorer classes, that is to say, living under detestable hygienic conditions, AND HAVE HAD NO OTHER TREATMENT THAN THE OZONE INHALATIONS FOR A QUARTER OF AN HOUR EACH DAY AND THAT FOR A NUMBER OF THEM, DURING A LONG AND RIGOROUS WINTER.
WE ARE ABSOLUTELY CONVINCED, AND SEVERAL CASES ACTUALLY OBSERVED, ENABLE US TO AFFIRM, THAT BY LONGER AND MORE FREQUENT INHALATIONS, THERE CAN BE OBTAINED THERAPEUTIC RESULTS MUCH MORE RAPID, MORE COMPLETE AND STILL MORE CONCLUSIVE.
In "Report to Paris Congress for the Study of Tuberculosis"